Protein Details: Gamma-aminobutyric acid receptor exp-1

Protein ID

ICDB_Pro_0145

Protein Name

Gamma-aminobutyric acid receptor exp-1

Gene Name

exp-1; H35N03.1

Organism

Caenorhabditis elegans

Length

539 amino acids

AlphaFoldDB

AF-G5ECJ0-F1-model_v4.pdb

Function

GABA receptor that functions as an excitatory cation channel. Permeable to monovalent cations such as Na(+) and K(+). Has negligible divalent cation permeability. Does not act as a chloride channel. Mediates enteric muscle contractions required for defecation. Probably by regulating the defecation motor program; required for fatty acid uptake by intestinal cells.

Sequence

MSASILILATCHQVLADFNSYVVPQPHAQRDHRQDISQHYDYLMEENDEPLGRGAAPSKYRSSHGQAQHRPEMTESENFAQPNTESVFSSGGVDSYGETRDFLQFLRRIQYDHRQVPENEKGEATYVEVSVVVSNIRAVSEVTMDYALELFYRESWRDPRLQYDRKLFKNKTELALHESYTNFLWFPDTFVPNAIASKNPQRNSISHRSLLRLDETGKLLYSRRISLVCECTMDLTLFPFDKQLCKLGIESYGYTADHVVYKWSKGARTALELKKIRLPDFTIQEAYVTSQMESYATGNYSRLYVCFVFSRSSGFCFLQLIIPSTAVVITSWVSLWMETETEFQDMISIILAITFLIFSYNEMMPRVSYIKAMDIYLGVCFMIVFLSLIKLALVKYMRQKIMLTSDSGNSLREMSQMSTRQRLRARKTSNMNFRNNGGGSIPINEEHQQMLTVPNGEDKMANGDDKEANNNGKSHLSDMLEIRITQRTMHRFHWISQMLFFFGFVIFCLFYFLIYPNLHIVSVDPACDKNLAEWFADIY

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Expressed in the intestinal and anal depressor muscles but not in the sphincter muscle. Also detected in the RID and SABD ring interneurons; the ADE sensory neuron and the PDA motor neuron.

DOI ID

10.1038/nn1136; 10.1126/science.282.5396.2012; 10.1093/genetics/124.4.855; 10.1242/dev.02069; 10.1016/j.jmb.2005.07.032; 10.1371/journal.pone.0124515

RefSeq

NP_495229.3 [G5ECJ0-1]